๐Ÿงฌ ์•” ์˜ˆ๋ฐฉ ๋ฐ ํ•ญ์•”๊ธฐ์ „ ๊ด€๋ จ ์—ฐ๊ตฌ ์ •๋ฆฌ

์ „์ฒด ๊ฒŒ์‹œ๊ธ€ ์ˆ˜ : 14 posts

์‚ผ์ค‘ ์Œ์„ฑ ์œ ๋ฐฉ์•” ๋ชจ๋ธ์—์„œ ์‹์ด ์„คํฌ๋ผํŒ์˜ ํ•ญ์ข…์–‘ ๋ฐ ํ•ญ์ „์ด ํšจ๊ณผ

<div></div> ์ด ๋ฌธ์„œ๋Š” ์‚ผ์ค‘ ์Œ์„ฑ ์œ ๋ฐฉ์•” ๋ชจ๋ธ์—์„œ ์‹์ด ์„คํฌ๋ผํŒ์˜ ํ•ญ์ข…์–‘ ๋ฐ ํ•ญ์ „์ด ํšจ๊ณผ ๋ฅผ ํ•œ๊ตญ์–ด๋กœ ํ’€์–ด ์ •๋ฆฌํ•œ ๊ฐœ๋ณ„ paper์ž…๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์ด ๋‹ค๋ฃจ๋Š” ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์‹์ด ๋†๋„์˜ ์„คํฌ๋ผํŒ์ด TNBC ๋ชจ๋ธ์—์„œ ์–ด๋–ค ๋ณ€ํ™”๋ฅผ ๋ณด์˜€๋Š”๊ฐ€ ์ข…์–‘ ๋ฏธ์„ธํ™˜๊ฒฝ๊ณผ ์ „์ด ์–ต์ œ ํ•ด์„์€ ์–ด๋–ค ๊ทผ๊ฑฐ๋กœ ์ œ์‹œ๋˜๋Š”๊ฐ€ ๋™๋ฌผ๋ชจ๋ธ ๊ฒฐ๊ณผ๋ฅผ ์‚ฌ๋žŒ ์ ์šฉ์œผ๋กœ ์—ฐ๊ฒฐํ•  ๋•Œ ์–ด๋–ค ํ•œ๊ณ„๊ฐ€ ์žˆ๋Š”๊ฐ€ Pogorzelska et al., 2024 <h2>๋ฉ”ํƒ€๋ฆฌ๋ทฐ์•ˆ๋‚ด</h2> ์ด ์—ฐ๊ตฌ๋Š” ๊ณต๊ฒฉ์ ์ธ ์œ ๋ฐฉ์•” ์œ ํ˜•์ธ TNBC ๋ชจ๋ธ์—์„œ, ์‹์ด ์„ญ์ทจ ์ˆ˜์ค€์˜ ์ €๋†๋„

์„คํฌ๋ผํŒ์˜ ํ™”ํ•™์  ๋ฏผ๊ฐ์ œ ์ž ์žฌ๋ ฅ ํ™œ์šฉ: ์ข…ํ•ฉ ๊ฒ€ํ† 

<div></div> ์ด ๋ฌธ์„œ๋Š” ์„คํฌ๋ผํŒ์˜ ํ™”ํ•™์  ๋ฏผ๊ฐ์ œ ์ž ์žฌ๋ ฅ ํ™œ์šฉ: ์ข…ํ•ฉ ๊ฒ€ํ†  ๋ฅผ ํ•œ๊ตญ์–ด๋กœ ํ’€์–ด ์ •๋ฆฌํ•œ ๊ฐœ๋ณ„ paper์ž…๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์ด ๋‹ค๋ฃจ๋Š” ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์„คํฌ๋ผํŒ์ด ํ•ญ์•”์ œ ์ €ํ•ญ์„ฑ์„ ๋‚ฎ์ถ”๋Š” ์ฃผ์š” ๊ฒฝ๋กœ๋Š” ๋ฌด์—‡์ธ๊ฐ€ ํ™”ํ•™์  ๋ฏผ๊ฐ์ œ๋ผ๋Š” ํ•ด์„์ด ์–ด๋–ค ๊ทผ๊ฑฐ์—์„œ ๋‚˜์˜ค๋Š”๊ฐ€ ์ž„์ƒ ์ ์šฉ ์‹œ ๋‚ฎ์€ ์ƒ์ฒด ์ด์šฉ๋ฅ ์€ ์–ด๋–ค ์ œ์•ฝ์„ ๋งŒ๋“œ๋Š”๊ฐ€ Sailo et al. (2024) <h2>๋ฉ”ํƒ€๋ฆฌ๋ทฐ ์•ˆ๋‚ด</h2> ์ด ๋ฆฌ๋ทฐ๋Š” ์‹ญ์žํ™”๊ณผ ์ฑ„์†Œ ์œ ๋ž˜ ์„คํฌ๋ผํŒ(SFN)์ด ์—ฌ๋Ÿฌ ์‹ ํ˜ธ ๊ฒฝ๋กœ์— ์ž‘์šฉํ•ด ์•”์„ธํฌ์˜ ํ•ญ์•”์ œ ์ €ํ•ญ์„ฑ์„ ๋‚ฎ์ถ”๊ณ , ๊ธฐ์กด ์น˜๋ฃŒ ํšจ๊ณผ๋ฅผ

์‹๋ฌผ ์œ ๋ž˜ ์ฒœ์—ฐ ์†Œ๋ถ„์ž ํ™”ํ•ฉ๋ฌผ์ธ ์„คํฌ๋ผํŒ์— ์˜ํ•œ ์•” ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์˜ ์ž ์žฌ์  ๋ฉ”์ปค๋‹ˆ์ฆ˜

<div></div> ์ด ๋ฌธ์„œ๋Š” ์‹๋ฌผ ์œ ๋ž˜ ์ฒœ์—ฐ ์†Œ๋ถ„์ž ํ™”ํ•ฉ๋ฌผ์ธ ์„คํฌ๋ผํŒ์— ์˜ํ•œ ์•” ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์˜ ์ž ์žฌ์  ๋ฉ”์ปค๋‹ˆ์ฆ˜ ๋ฅผ ํ•œ๊ตญ์–ด๋กœ ํ’€์–ด ์ •๋ฆฌํ•œ ๊ฐœ๋ณ„ paper์ž…๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์ด ๋‹ค๋ฃจ๋Š” ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์„คํฌ๋ผํŒ์˜ ์•” ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ ๊ธฐ์ „์€ ์–ด๋–ป๊ฒŒ ๋ฌถ์ด๋Š”๊ฐ€ ์ „๋‹ฌ ๊ธฐ์ˆ ๊ณผ ์ƒ์ฒด ์ด์šฉ๋ฅ  ๋ฌธ์ œ๋Š” ์–ด๋–ป๊ฒŒ ์ •๋ฆฌ๋˜๋Š”๊ฐ€ ์ž„์ƒ ์ ์šฉ์„ ์œ„ํ•ด ์–ด๋–ค ๋ณด์™„ ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•œ๊ฐ€ Liu et al. (2024) <h2>๋ฉ”ํƒ€๋ฆฌ๋ทฐ์•ˆ๋‚ด</h2> ์ด ๋ฆฌ๋ทฐ๋Š” ์•” ์‚ฌ๋ง๋ฅ  ์ฆ๊ฐ€์™€ ๊ธฐ์กด ํ™”ํ•™์š”๋ฒ•์˜ ํ•œ๊ณ„๋ฅผ ๋ฐฐ๊ฒฝ์œผ๋กœ, ๋ธŒ๋กœ์ฝœ๋ฆฌ ์œ ๋ž˜ ์„คํฌ๋ผํŒ(SFN)์ด Nrf2 ๊ธฐ๋ฐ˜

์„คํฌ๋ผํŒ์˜ ํ•ญ์•” ํŠน์„ฑ: ๋ถ„์ž ์ˆ˜์ค€์—์„œ์˜ ํ˜„์žฌ ํ†ต์ฐฐ

<div></div> ์ด ๋ฌธ์„œ๋Š” ์„คํฌ๋ผํŒ์˜ ํ•ญ์•” ํŠน์„ฑ: ๋ถ„์ž ์ˆ˜์ค€์—์„œ์˜ ํ˜„์žฌ ํ†ต์ฐฐ ๋ฅผ ํ•œ๊ตญ์–ด๋กœ ํ’€์–ด ์ •๋ฆฌํ•œ ๊ฐœ๋ณ„ paper์ž…๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์ด ๋‹ค๋ฃจ๋Š” ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์„คํฌ๋ผํŒ์ด ์–ด๋–ค ๋ถ„์ž ๊ฒฝ๋กœ๋ฅผ ํ†ตํ•ด ํ•ญ์•” ์ž‘์šฉ์„ ์„ค๋ช…ํ•˜๋Š”๊ฐ€ ํ›„์„ฑ์œ ์ „ํ•™ ์กฐ์ ˆ์ด ํ•ต์‹ฌ ๊ทผ๊ฑฐ๋กœ ์–ด๋–ป๊ฒŒ ์ œ์‹œ๋˜๋Š”๊ฐ€ ์ž„์ƒ ์ ์šฉ ์ „ ๋‚จ์•„ ์žˆ๋Š” ํ•œ๊ณ„๋Š” ๋ฌด์—‡์ธ๊ฐ€ Asif Ali et al., 2023 <h2>๋ฉ”ํƒ€๋ฆฌ๋ทฐ์•ˆ๋‚ด</h2> ์ด ๋…ผ๋ฌธ์€ ๋ธŒ๋กœ์ฝœ๋ฆฌ ์œ ๋ž˜ ์„คํฌ๋ผํŒ(SFN)์ด HDAC ์–ต์ œ ๋ฅผ ํฌํ•จํ•œ ์—ฌ๋Ÿฌ ํ›„์„ฑ์œ ์ „ํ•™ยท๋น„ํ›„์„ฑ์œ ์ „ํ•™ ๊ฒฝ๋กœ์— ์ž‘์šฉํ•ด ํ•ญ์•” ํšจ๊ณผ๋ฅผ ๋ณด์ผ ์ˆ˜ ์žˆ๋‹ค๋Š”

์ง„ํ–‰์„ฑ ์ทŒ์žฅ์•”์—์„œ ๋ธŒ๋กœ์ฝœ๋ฆฌ ์ƒˆ์‹น ๋ณด์ถฉ ์ธ์ฒด์—ฐ๊ตฌ ๋ฉ”ํƒ€๋ถ„์„๋ฆฌํฌํŠธ

์ด ๋‹จ๋…๋ณธ์€ ์ง„ํ–‰์„ฑ ์ทŒ์žฅ์•” ํ™˜์ž์—๊ฒŒ broccoli sprout ์บก์А์„ ๊ณ ์šฉ๋Ÿ‰์œผ๋กœ ์žฅ๊ธฐ๊ฐ„ ํˆฌ์—ฌํ–ˆ์„ ๋•Œ, ์ƒ์กด์œจ ๊ฒฝํ–ฅ๊ณผ ์‹ค์ œ ๋ณต์šฉ ๊ฐ€๋Šฅ์„ฑ์„ ํ•จ๊ป˜ ๋ณธ ํŒŒ์ผ๋Ÿฟ ์‚ฌ๋žŒ ์—ฐ๊ตฌ๋ฅผ ์ •๋ฆฌํ•œ ๋ฉ”ํƒ€๋ฆฌ๋ทฐ์ž…๋‹ˆ๋‹ค. ํ•ต์‹ฌ ์งˆ๋ฌธ ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ์ง„ํ–‰์„ฑ ์ทŒ์žฅ์•” ํ™˜์ž์—๊ฒŒ ๊ณ ์šฉ๋Ÿ‰ broccoli sprout ๊ธฐ๋ฐ˜ ์„คํฌ๋ผํŒ ๊ฐœ์ž…์„ ์žฅ๊ธฐ๊ฐ„ ์ ์šฉํ•˜๋Š” ๊ฒƒ์ด ์‹ค์ œ๋กœ ๊ฐ€๋Šฅํ•œ๊ฐ€, ๊ทธ๋ฆฌ๊ณ  ์ƒ์กด์œจ ๋ฐฉํ–ฅ์—์„œ ์–ด๋–ค ์‹ ํ˜ธ๊ฐ€ ์žˆ์—ˆ๋Š”๊ฐ€์ž…๋‹ˆ๋‹ค. ํ•œ์ค„์š”์•ฝ ์ง„ํ–‰์„ฑ ์ทŒ์žฅ์•” ํ™˜์ž 40๋ช…์„ ๋Œ€์ƒ์œผ๋กœ ํ•œ placebo ๋น„๊ต pilot study์ž…๋‹ˆ๋‹ค. SFN 90 mg/day + GR 180

์œ ๋ฐฉ ์ƒ๊ฒ€ ์˜ˆ์ • ์—ฌ์„ฑ์—์„œ ๊ธ€๋ฃจ์ฝ”๋ผํŒŒ๋‹Œ ๋ณด์ถฉ ์ธ์ฒด์—ฐ๊ตฌ ๋ฉ”ํƒ€๋ถ„์„๋ฆฌํฌํŠธ

์ด ๋‹จ๋…๋ณธ์€ ์œ ๋ฐฉ ์ƒ๊ฒ€์ด ์˜ˆ์ •๋œ ์—ฌ์„ฑ์„ ๋Œ€์ƒ์œผ๋กœ glucoraphanin ๋ณด์ถฉ์ œ๋ฅผ ์งง๊ฒŒ ํˆฌ์—ฌํ–ˆ์„ ๋•Œ, ํ˜ˆ์•ก๊ณผ ์œ ๋ฐฉ ์กฐ์ง์˜ chemoprevention ๊ด€๋ จ ๋ฐ”์ด์˜ค๋งˆ์ปค๊ฐ€ ์–ด๋–ค ๋ฐฉํ–ฅ์œผ๋กœ ์›€์ง์˜€๋Š”์ง€ ์ •๋ฆฌํ•œ ๋ฉ”ํƒ€๋ฆฌ๋ทฐ์ž…๋‹ˆ๋‹ค. ํ•ต์‹ฌ ์งˆ๋ฌธ ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ์œ ๋ฐฉ์•” ์˜์—ญ์—์„œ ๊ฒฝ๊ตฌ glucoraphanin ๋ณด์ถฉ์ด ์กฐ์ง ๋ฐ”์ด์˜ค๋งˆ์ปค๋ฅผ ๋ฐ”๊ฟ€ ์ˆ˜ ์žˆ๋Š”๊ฐ€์ž…๋‹ˆ๋‹ค. ํ•œ์ค„์š”์•ฝ ์œ ๋ฐฉ ์ƒ๊ฒ€ ์˜ˆ์ • ์—ฌ์„ฑ 54๋ช…์„ ๋Œ€์ƒ์œผ๋กœ ํ•œ ๋ฌด์ž‘์œ„ ์ด์ค‘๋งน๊ฒ€ ์œ„์•ฝ ๋Œ€์กฐ ์—ฐ๊ตฌ์ž…๋‹ˆ๋‹ค. glucoraphanin 224 mg/day๋ฅผ ์ตœ์†Œ 2์ฃผ, ์ตœ๋Œ€ 8์ฃผ ์ ์šฉํ–ˆ์Šต๋‹ˆ๋‹ค. benign

์‚ผ์ค‘ ์Œ์„ฑ ์œ ๋ฐฉ์•” ๋ชจ๋ธ์—์„œ ์‹์ด ์„คํฌ๋ผํŒ์˜ ํ•ญ์ข…์–‘ ๋ฐ ํ•ญ์ „์ด ํšจ๊ณผ

<div></div> ์ด ๋ฌธ์„œ๋Š” ์‚ผ์ค‘ ์Œ์„ฑ ์œ ๋ฐฉ์•” ๋ชจ๋ธ์—์„œ ์‹์ด ์„คํฌ๋ผํŒ์˜ ํ•ญ์ข…์–‘ ๋ฐ ํ•ญ์ „์ด ํšจ๊ณผ ๋ฅผ ํ•œ๊ตญ์–ด๋กœ ํ’€์–ด ์ •๋ฆฌํ•œ ๊ฐœ๋ณ„ paper์ž…๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์ด ๋‹ค๋ฃจ๋Š” ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์‹์ด ๋†๋„์˜ ์„คํฌ๋ผํŒ์ด TNBC ๋ชจ๋ธ์—์„œ ์–ด๋–ค ๋ณ€ํ™”๋ฅผ ๋ณด์˜€๋Š”๊ฐ€ ์ข…์–‘ ๋ฏธ์„ธํ™˜๊ฒฝ๊ณผ ์ „์ด ์–ต์ œ ํ•ด์„์€ ์–ด๋–ค ๊ทผ๊ฑฐ๋กœ ์ œ์‹œ๋˜๋Š”๊ฐ€ ๋™๋ฌผ๋ชจ๋ธ ๊ฒฐ๊ณผ๋ฅผ ์‚ฌ๋žŒ ์ ์šฉ์œผ๋กœ ์—ฐ๊ฒฐํ•  ๋•Œ ์–ด๋–ค ํ•œ๊ณ„๊ฐ€ ์žˆ๋Š”๊ฐ€ Pogorzelska et al., 2024 <h2>๋ฉ”ํƒ€๋ฆฌ๋ทฐ์•ˆ๋‚ด</h2> ์ด ์—ฐ๊ตฌ๋Š” ๊ณต๊ฒฉ์ ์ธ ์œ ๋ฐฉ์•” ์œ ํ˜•์ธ TNBC ๋ชจ๋ธ์—์„œ, ์‹์ด ์„ญ์ทจ ์ˆ˜์ค€์˜ ์ €๋†๋„

์„คํฌ๋ผํŒ์˜ ํ™”ํ•™์  ๋ฏผ๊ฐ์ œ ์ž ์žฌ๋ ฅ ํ™œ์šฉ: ์ข…ํ•ฉ ๊ฒ€ํ† 

<div></div> ์ด ๋ฌธ์„œ๋Š” ์„คํฌ๋ผํŒ์˜ ํ™”ํ•™์  ๋ฏผ๊ฐ์ œ ์ž ์žฌ๋ ฅ ํ™œ์šฉ: ์ข…ํ•ฉ ๊ฒ€ํ†  ๋ฅผ ํ•œ๊ตญ์–ด๋กœ ํ’€์–ด ์ •๋ฆฌํ•œ ๊ฐœ๋ณ„ paper์ž…๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์ด ๋‹ค๋ฃจ๋Š” ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์„คํฌ๋ผํŒ์ด ํ•ญ์•”์ œ ์ €ํ•ญ์„ฑ์„ ๋‚ฎ์ถ”๋Š” ์ฃผ์š” ๊ฒฝ๋กœ๋Š” ๋ฌด์—‡์ธ๊ฐ€ ํ™”ํ•™์  ๋ฏผ๊ฐ์ œ๋ผ๋Š” ํ•ด์„์ด ์–ด๋–ค ๊ทผ๊ฑฐ์—์„œ ๋‚˜์˜ค๋Š”๊ฐ€ ์ž„์ƒ ์ ์šฉ ์‹œ ๋‚ฎ์€ ์ƒ์ฒด ์ด์šฉ๋ฅ ์€ ์–ด๋–ค ์ œ์•ฝ์„ ๋งŒ๋“œ๋Š”๊ฐ€ Sailo et al. (2024) <h2>๋ฉ”ํƒ€๋ฆฌ๋ทฐ ์•ˆ๋‚ด</h2> ์ด ๋ฆฌ๋ทฐ๋Š” ์‹ญ์žํ™”๊ณผ ์ฑ„์†Œ ์œ ๋ž˜ ์„คํฌ๋ผํŒ(SFN)์ด ์—ฌ๋Ÿฌ ์‹ ํ˜ธ ๊ฒฝ๋กœ์— ์ž‘์šฉํ•ด ์•”์„ธํฌ์˜ ํ•ญ์•”์ œ ์ €ํ•ญ์„ฑ์„ ๋‚ฎ์ถ”๊ณ , ๊ธฐ์กด ์น˜๋ฃŒ ํšจ๊ณผ๋ฅผ

์‹๋ฌผ ์œ ๋ž˜ ์ฒœ์—ฐ ์†Œ๋ถ„์ž ํ™”ํ•ฉ๋ฌผ์ธ ์„คํฌ๋ผํŒ์— ์˜ํ•œ ์•” ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์˜ ์ž ์žฌ์  ๋ฉ”์ปค๋‹ˆ์ฆ˜

<div></div> ์ด ๋ฌธ์„œ๋Š” ์‹๋ฌผ ์œ ๋ž˜ ์ฒœ์—ฐ ์†Œ๋ถ„์ž ํ™”ํ•ฉ๋ฌผ์ธ ์„คํฌ๋ผํŒ์— ์˜ํ•œ ์•” ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์˜ ์ž ์žฌ์  ๋ฉ”์ปค๋‹ˆ์ฆ˜ ๋ฅผ ํ•œ๊ตญ์–ด๋กœ ํ’€์–ด ์ •๋ฆฌํ•œ ๊ฐœ๋ณ„ paper์ž…๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์ด ๋‹ค๋ฃจ๋Š” ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์„คํฌ๋ผํŒ์˜ ์•” ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ ๊ธฐ์ „์€ ์–ด๋–ป๊ฒŒ ๋ฌถ์ด๋Š”๊ฐ€ ์ „๋‹ฌ ๊ธฐ์ˆ ๊ณผ ์ƒ์ฒด ์ด์šฉ๋ฅ  ๋ฌธ์ œ๋Š” ์–ด๋–ป๊ฒŒ ์ •๋ฆฌ๋˜๋Š”๊ฐ€ ์ž„์ƒ ์ ์šฉ์„ ์œ„ํ•ด ์–ด๋–ค ๋ณด์™„ ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•œ๊ฐ€ Liu et al. (2024) <h2>๋ฉ”ํƒ€๋ฆฌ๋ทฐ์•ˆ๋‚ด</h2> ์ด ๋ฆฌ๋ทฐ๋Š” ์•” ์‚ฌ๋ง๋ฅ  ์ฆ๊ฐ€์™€ ๊ธฐ์กด ํ™”ํ•™์š”๋ฒ•์˜ ํ•œ๊ณ„๋ฅผ ๋ฐฐ๊ฒฝ์œผ๋กœ, ๋ธŒ๋กœ์ฝœ๋ฆฌ ์œ ๋ž˜ ์„คํฌ๋ผํŒ(SFN)์ด Nrf2 ๊ธฐ๋ฐ˜

์„คํฌ๋ผํŒ์˜ ํ•ญ์•” ํŠน์„ฑ: ๋ถ„์ž ์ˆ˜์ค€์—์„œ์˜ ํ˜„์žฌ ํ†ต์ฐฐ

<div></div> ์ด ๋ฌธ์„œ๋Š” ์„คํฌ๋ผํŒ์˜ ํ•ญ์•” ํŠน์„ฑ: ๋ถ„์ž ์ˆ˜์ค€์—์„œ์˜ ํ˜„์žฌ ํ†ต์ฐฐ ๋ฅผ ํ•œ๊ตญ์–ด๋กœ ํ’€์–ด ์ •๋ฆฌํ•œ ๊ฐœ๋ณ„ paper์ž…๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์ด ๋‹ค๋ฃจ๋Š” ํ•ต์‹ฌ ์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์„คํฌ๋ผํŒ์ด ์–ด๋–ค ๋ถ„์ž ๊ฒฝ๋กœ๋ฅผ ํ†ตํ•ด ํ•ญ์•” ์ž‘์šฉ์„ ์„ค๋ช…ํ•˜๋Š”๊ฐ€ ํ›„์„ฑ์œ ์ „ํ•™ ์กฐ์ ˆ์ด ํ•ต์‹ฌ ๊ทผ๊ฑฐ๋กœ ์–ด๋–ป๊ฒŒ ์ œ์‹œ๋˜๋Š”๊ฐ€ ์ž„์ƒ ์ ์šฉ ์ „ ๋‚จ์•„ ์žˆ๋Š” ํ•œ๊ณ„๋Š” ๋ฌด์—‡์ธ๊ฐ€ Asif Ali et al., 2023 <h2>๋ฉ”ํƒ€๋ฆฌ๋ทฐ์•ˆ๋‚ด</h2> ์ด ๋…ผ๋ฌธ์€ ๋ธŒ๋กœ์ฝœ๋ฆฌ ์œ ๋ž˜ ์„คํฌ๋ผํŒ(SFN)์ด HDAC ์–ต์ œ ๋ฅผ ํฌํ•จํ•œ ์—ฌ๋Ÿฌ ํ›„์„ฑ์œ ์ „ํ•™ยท๋น„ํ›„์„ฑ์œ ์ „ํ•™ ๊ฒฝ๋กœ์— ์ž‘์šฉํ•ด ํ•ญ์•” ํšจ๊ณผ๋ฅผ ๋ณด์ผ ์ˆ˜ ์žˆ๋‹ค๋Š”

ํ์•” ๊ณ ์œ„ํ—˜ former smokers์—์„œ ์„คํฌ๋ผํŒ 12๊ฐœ์›” ์ธ์ฒด์—ฐ๊ตฌ ๋ฉ”ํƒ€๋ถ„์„๋ฆฌํฌํŠธ

ํ์•” ๊ณ ์œ„ํ—˜ former smokers์—๊ฒŒ ์„คํฌ๋ผํŒ ๊ด€๋ จ ๊ฐœ์ž…์„ 12๊ฐœ์›” ์ ์šฉํ–ˆ์„ ๋•Œ, ๊ธฐ๊ด€์ง€ ์กฐ์ง์˜ Ki-67๊ฐ€ ์œ„์•ฝ๊ตฐ๋ณด๋‹ค ์œ ์˜ํ•˜๊ฒŒ ๋” ๋‚ฎ์•„์กŒ์Šต๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์€ ์น˜๋ฃŒ ์—ฐ๊ตฌ๊ฐ€ ์•„๋‹ˆ๋ผ chemoprevention-support ์„ฑ๊ฒฉ์˜ ์ง์ ‘ ์ธ๊ฐ„ ๊ทผ๊ฑฐ์ž…๋‹ˆ๋‹ค.

์žฌ๋ฐœ ์ „๋ฆฝ์„ ์•”์—์„œ ๋ธŒ๋กœ์ฝœ๋ฆฌ ์ƒˆ์‹น ์ถ”์ถœ๋ฌผ 20์ฃผ ์ธ์ฒด์—ฐ๊ตฌ ๋ฉ”ํƒ€๋ถ„์„๋ฆฌํฌํŠธ

์žฌ๋ฐœ ์ „๋ฆฝ์„ ์•” ํ™˜์ž์—๊ฒŒ sulforaphane-rich broccoli sprout extract 200 ยตmol/day๋ฅผ ์ตœ๋Œ€ 20์ฃผ ํˆฌ์—ฌํ–ˆ์„ ๋•Œ, 1์ฐจ ๋ชฉํ‘œ๋Š” ๋ฏธ๋‹ฌํ–ˆ์ง€๋งŒ PSA doubling time์€ ์œ ์˜ํ•˜๊ฒŒ ๋Š˜์–ด๋‚ฌ์Šต๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์€ ์ „๋ฆฝ์„ ์•” ์žฌ๋ฐœ ์ถ•์˜ ๋ณด์™„ ์ธ๊ฐ„ ๊ทผ๊ฑฐ์ž…๋‹ˆ๋‹ค.

์ „๋ฆฝ์„ ์•” ์žฌ๋ฐœ ํ™˜์ž์—์„œ ์œ ๋ฆฌ ์„คํฌ๋ผํŒ 60mg 6๊ฐœ์›” ์ธ์ฒด์—ฐ๊ตฌ ๋ฉ”ํƒ€๋ถ„์„๋ฆฌํฌํŠธ

์ „๋ฆฝ์„  ์ ˆ์ œ์ˆ  ํ›„ PSA๊ฐ€ ๋‹ค์‹œ ์˜ค๋ฅด๋Š” ์ƒํ™”ํ•™์  ์žฌ๋ฐœ ํ™˜์ž์—์„œ free sulforaphane 60 mg/day๋ฅผ 6๊ฐœ์›” ํˆฌ์—ฌํ•˜์ž, PSA ์ƒ์Šนํญ๊ณผ PSA doubling time์ด ์œ„์•ฝ๊ตฐ๋ณด๋‹ค ๋” ์œ ๋ฆฌํ•œ ๋ฐฉํ–ฅ์„ ๋ณด์˜€์Šต๋‹ˆ๋‹ค. ์ด ๋…ผ๋ฌธ์€ ๋งŒ๋จน์„ค ํด๋ฆฌ์–ด 60M6์˜ ๊ฐ€์žฅ ๊ฐ•ํ•œ ์ง์ ‘ ์ธ๊ฐ„ ๊ทผ๊ฑฐ์ž…๋‹ˆ๋‹ค.

์„คํฌ๋ผํŒ์˜ ์•” ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์— ๋Œ€ํ•œ ๋ถ„์ž ๊ธฐ์ „ ์—ฐ๊ตฌ ๋…ผ๋ฌธ

์„คํฌ๋ผํŒ์€ ๋‹จ์ˆœํ•œ ํ•ญ์‚ฐํ™” ์„ฑ๋ถ„์ด ์•„๋‹ˆ๋ผ, ์•” ๋ฐœ์ƒ ์ดˆ๊ธฐ์˜ ์˜ˆ๋ฐฉ๋ถ€ํ„ฐ ์น˜๋ฃŒ๊นŒ์ง€ ๋‹ค๋‹จ๊ณ„์—์„œ ์ž‘์šฉํ•˜๋Š” ๊ธฐ๋Šฅ์„ฑ ๋ฌผ์งˆ์ด๋ฉฐ, ์ •์ƒ์„ธํฌ ๋ณดํ˜ธ์™€ ์•”์„ธํฌ ์–ต์ œ๋ฅผ ๋™์‹œ์— ๋‹ฌ์„ฑํ•  ์ˆ˜ ์žˆ๋Š” ๋…ํŠนํ•œ ํŠน์„ฑ์„ ์ง€๋‹Œ๋‹ค.